Vicente del Bosque's side suffered an embarrassing group-stage exit at Brazil 2014, but have found some form again as they look to complete a hat-trick of European victories after glory at Euro 2008 and 2012.
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"We're the defending champions," Ramos told Fifa.com. "I've had the great privilege of winning it twice and I'd love to do it a third time.
"Some important players have retired, like Xavi and Xabi Alonso, two central midfielders who defined an era and gave a great balance to the national team.
"But today we've got a good blend of veterans and young players hungry to do big things. We can be confident with the team we've got but we'll let our football do the talking."