The Canarinho are heading into this match brimming with confidence after ending their group stage campaign with a 2-0 win over Serbia on Wednesday.
The victory secured Brazil a top spot finish in their group - two points above runners-up Switzerland.
Neymar and Philippe Coutinho have been the Canarrinho's best players at this year's competition.
Both players attackers are important for the squad and they have the ability to inspire the South American giants to victory against Mexico.
Brazil are the most successful country in this tournament having won a record five trophies since the inception of the competition in 1930.
Head coach Adenor Leonardo Bacchi, who is better known as Tite, is the man expected to guide Brazil to their sixth title.
Meanwhile, Mexico are a wounded team having lost 3-0 to Sweden in their last group match which was played on Wednesday.
Despite the heavy defeat, the Tricolor finished as runners-up in their group - only behind Sweden (group winners) on goal-difference.
Hirving Lozano and Javier Hernandez are key players in the Tricolor squad, having played an important role in helping the team reach the Round of 16.
The two speedy attackers have both scored in this year's tournament and they will look to help their nation stun Brazil.
Mexico have never won the this tournament and their best performance was when they reached the quarter-finals in 1970 and 1986 (as hosts).
Tricolors head coach Juan Carlos Osorio will be hoping to guide his charges to a famous win over Brazil. The last meeting between Brazil and Mexico was on the 7th of June 2015.
Back then The Canarinho overcame the Tricolor 2-0 in a friendly game in Sao Paolo.