Ronald Koeman's side will be eager to bounce back from the 2-1 defeat they suffered against France in their tournament opener, while Germany will be aiming to put more points on the board having drawn 0-0 with Les Bleus back in September.
The Dutch have a friendly game against their near neighbours Belgium to come the following Tuesday, but there is no let-up for Joachim Low's side, who must lock horns with Group 1 foes France once more.
Victory for Germany will set them up nicely heading into the crunch game against Didier Deschamps' world champions in Paris and it would also pile the pressure on Koeman by pushing his team closer to relegation.
|Game||Netherlands vs Germany|
|Date||Saturday, October 13|
|Time||7:45pm BST / 2:45pm ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|Univision Deportes||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on Sky Sports Mix and it can be streamed live online using Sky Go. The game can also be followed live on Goal here.
|UK TV channel||Online stream|
|Sky Sports Mix||Sky Go|
Squads & Team News
|Goalkeepers||Cillessen, Zoet, Bizot|
|Defenders||De Ligt, Van Dijk, Blind, De Vrij, Ake, Van Aanholt, Hateboer, Dumfries|
|Midfielders||F. de Jong, Wijnaldum, Strootman, Van de Beek, De Roon, Vilhena, Rosario|
|Forwards||Promes, Depay, Babel, L. de Jong, Bergwijn, Danjuma|
There is no place for Lyon defender Kenny Tete, who is injured along with Terence Kongolo and Timothy Fosu-Mensah. Davy Propper has also been forced to withdraw after sustaining an injury while playing for Brighton.
Roma's Justin Kluivert, Brugge midfielder Ruud Vormer and Wolsfburg forward Wout Weghorst were cut from the provisional panel. PSV trio Denzel Dumfries, Pablo Rosario and Steven Bergwijn could potentially make their senior national team debuts.
Potential Netherlands XI: Cillessen; De Ligt, Van Dijk, Dumfries, Blind; Wijnaldum, F. de Jong, Vilhena; Bergwijn, Depay, Babel.
|Goalkeepers||Neuer, Leno, Ter Stegen|
|Defenders||Kehrer, Hector, Ginter, Hummels, Schulz, Sule, Boateng|
|Midfielders||Gnabry, Draxler, Kroos, Brandt, Can, Kimmich, Sane, Rudy|
|Forwards||Werner, Muller, Uth|
Kevin Trapp and Leon Goretzka were named in the initial squad but have been replaced by Bernd Leno and Serge Gnabry respectively after sustaining injuries.
Antonio Rudiger, Kai Havertz and Marco Reus were also expected to be involved in the game but all three have been forced to withdraw due to injuries.
Schalke striker Mark Uth, who bagged 14 Bundesliga goals last season but has yet to score this term, could potentially win his first cap.
Potential Germany XI: Neuer; Ginter, Boateng, Hummels, Kimmich; Kroos, Can, Draxler; Werner, Muller, Sane.
Betting & Match Odds
Visitors Germany are strong favourites to win at 23/20 according to bet365. The Netherlands' chances of victory are rated 12/5 and a draw is deemed more likely than that at 11/4.
As the Netherlands get ready to host Germany in the Nations League on Saturday they do so knowing that they have not managed to beat their bitter rivals in their previous five attempts.
The last time the Oranje came out on top in a battle between the teams was November 2002, when goals from Patrick Kluivert, Jimmy Floyd Hasselbaink and Ruud van Nistelrooy were the difference in a 3-1 friendly victory. However, one must go back even further, to Euro 1992, for the last time the Dutch registered a competitive win against the Germans.
As well as that, the Netherlands are currently at a low ebb having missed out on a place at both Euro 2016 and the 2018 World Cup, so they come into the clash as serious underdogs, despite being at home. Nevertheless, Koeman remains positive about his side's chances, pointing to the Germans' own recent downturn in form.
"In my opinion, it's not a great period for the national team. We're used to fighting for trophies. On the other hand, we still have players who play for big clubs," the former Everton boss said ahead of the game.
"We have enough quality but it's not going to be an easy win for us against Germany. We have to play at our best against them, but I also think that Germany have known better times in football."
Four-time world champions Germany have indeed known better times and head coach Low is navigating uncomfortable terrain as he looks to steer the team through a period of transition. Shorn of stars such as Reus and Goretzka through injury, not to mention Mesut Ozil, the team is evolving, but it still features a lot of youthful talent.
Despite the difficulties, Low's men played out a hard-fought draw against world champions France last month and followed it up with a 2-1 win over Peru, so they will have no concerns ahead of the Amsterdam showdown.