Two wins and a draw in their three home group games, followed by victory over Zurich in the previous round of the Europa League underlines how strong Napoli have been in their own stadium. bet365 price a win for Ancelotti's side at 9/20 (1.45) with the visitors offered at 6/1 (7.00) and the draw at 10/3 (4.33).
Napoli remain without centre-back Raul Albiol with the former Real Madrid player having undergone knee surgery. Salzburg have a few injury doubts, with striker Fredrik Gulbrandsen and centre-back Marin Pongracic likely to miss out.
Salzburg's strong record in the Europa League this season will give them hope that they can at least claim an away goal in Naples.
The Austrian champions have scored in all eight of their matches so far in the competition, although Napoli will provide by far the strongest test they have faced.
Ancelotti's side will feel that the Europa League provides an excellent chance of silverware this term, given that they are sixteen points behind leaders Juventus and 8 points ahead of third placed Milan - the side who knocked them out of the Coppa Italia.
The Europa League should therefore be taken quite seriously by Napoli, and backing them to win a high-scoring game looks like a decent option.
Tips and predictions
Both teams to score is offered at 10/11 (1.91) and should draw some interest given Salzburg's scoring record. Napoli to win and concede looks tempting at 11/5 (3.20) while Napoli and over 2.5 goals is also a strong option at 6/5 (2.20).
Odds correct at the time of writing. Please gamble responsibly.