Both sides are performing well domestically and, despite crashing out of the Champions League at the group stage, these two teams will feel that they are more than capable of going all the way this competition.
Maurizio Sarri's side are unbeaten in 13 home matches in the Europa League and can be backed at 10/11 (1.91) with bet365 to seize the initiative in the tie with a win in Naples.
Dries Mertens is Napoli's top scorer this term and the 30-year-old Belgian would love to make a big impression on this competition ahead of the World Cup.
Another man looking to play his way into a place in Russia is Timo Werner, who is Leipzig's leading marksman this season.
Goals at both ends
There were goals at both ends in five of six games that both of these teams contested in the Champions League group stages, and bet365 go 8/13 (1.62) that the trend continues in this clash.
The same firm also offers 8/11 (1.73) that there are at least three goals scored.
Tips and predictions
Napoli have won nine of their last 13 home matches in this competition may prove to be too good for the Bundesliga outfit in Thursday's first leg clash.
Leipzig, however, can make their mark and bet365's 13/5 (3.60) quote for the hosts to claim victory from a match in which both teams are on target could represent good value for punters here.
Odds correct at time of writing. Please gamble responsibly.