The Terriers enjoyed a 2-1 win against Manchester United at John Smith's Stadium back in October, but Jose Mourinho's men have been beaten in just one of their last 47 fixtures on home soil.
Huddersfield have won just one of their last 11 Premier League matches away from home, but David Wagner's team can be backed at a chunky 22/1 (23.0) with Betfair Sportsbook to do the double over Mourinho's side.
Alexis Sanchez is in line to make his home debut following his move from Arsenal last month.
Elias Kachunga misses out for the visitors, but the Terriers have no fresh injury concerns ahead of the trip to Old Trafford.
Defensive discipline key for United?
Manchester United have kept four clean sheets in their last five matches at Old Trafford and Betfair Sportsbook go 4/7 (1.57) that Mourinho's side keep Huddersfield at bay.
The same firm also offer 4/6 (1.67) that United win to nil - a selection that would have landed in 11 of the 14 home wins that Manchester United have recorded this term.
The case for goals
The addition of Sanchez from Arsenal could add to the home side's potency and Betfair Sportsbook go 5/6 (1.83) that Man United score more than two goals against the Terriers.
The price of 11/8 (2.38) on at least four goals being scored in this game also appeals.
Tips and predictions:
Huddersfield have failed to score in nine of their last 11 away matches in this competition and Wagner's side may struggle to make much of an impact in Manchester.
Mourinho's side are expected to win well here and Betfair Sportsbook's 6/5 (2.20) quote for Manchester United to win both halves may represent a solid selection for punters.
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