Marouane Fellaini starts for the first time this season in place of the injured Paul Pogba for Manchester United's clash with Everton.
Romelu Lukaku also lines up against his former club, with Juan Mata also coming back into the team.
Ashley Young retains his place but moves across the defence to left-back while Phil Jones and Eric Bailly return having been suspended against Basel in midweek.
United have won 18 and lost just one of their last 24 Premier League home games against the Toffees, losing 0-1 in December 2013 while former Everton boss David Moyes was in charge of them.
Everton, meanwhile, have Wayne Rooney leading the line on his return to Old Trafford as they look for a first win since the opening day of the Premier League season.
Tom Davies looks set to start on the right-hand side of midield as Ronald Koeman starts with with a slightly more defensive formation.
Manchester United XI : De Gea, Valencia, Jones, Bailly, Young, Matic, Fellaini, Mkhitaryan, Mata, Rashford, Lukaku.
Everton XI: Pickford, Holgate, Keane, Jagielka, Williams, Baines, Davies, Gueye, Schneiderlin, Sigurdsson, Rooney.