Pep Guardiola's men have won five consecutive matches to move a point clear of Liverpool, who are not in action until Sunday.
Having won each of their last nine games against this opposition, they are 1/7 (1.14) favourites with bet365 to tighten their grip on top spot with another victory.
The Hornets have actually only lost twice in 13 fixtures in all competitions, but remain 16/1 (17.00) outsiders to upset the hosts in their own back yard for the first time since 1987.
None of the champions' last 21 league matches have resulted in draws, but you can get odds of 13/2 (7.50) on them being forced to settle for a single point in this one.
Kevin De Bruyne, Fernandinho, Aymeric Laporte, John Stones, and Benjamin Mendy are all sidelined, although Fabian Delph could be in line for a comeback after returning to training.
Kiko Femenia remains a doubt due to injury, although Miguel Britos could be back in contention after missing the 2-1 win over Leicester due to illness.
While they have kept on winning, the Citizens have been made to work hard for a breakthrough in recent matches.
Indeed, they have only scored one first-half goal in their last five fixtures, with the two most recent home games resulting in narrow 1-0 victories following goalless opening periods.
Having conceded prior to the break in just two of their last eight games, Javi Gracia's side may back themselves to put up some resistance in the home of the leaders on Saturday.
All in all, odds of 10/11 (1.91) offer solid value on the majority of the goalmouth action taking place after half-time for Watford's seventh game in nine, and their second meeting of the season with City.
Odds correct at the time of writing. Please gamble responsibly.