The Citizens enjoyed a historic Premier League season last campaign, winning the title with a record a points haul, goal difference, and winning margin over second place.
However, with 16 of their players absent after taking part in the World Cup, they are 21/10 (3.10) outsiders with dabblebet to get this season off to a winning start in the USA.
These sides shared a 1-1 draw when they met in this competition two years ago, and are priced at 5/2 (3.50) to take this one to a penalty shootout with another stalemate.
Having contributed more players to the World Cup than any other team, Claudio Bravo, Leroy Sane, Aymeric Laporte, Joe Hart, and new signing Riyad Mahrez are the only senior members of Pep Guardiola’s young squad.
Similarly, Die Schwarzgelben will be without the likes of Marco Reus, Lukasz Piszczek, Manuel Akanji, as well as new signings Ashraf Hakimi and Thomas Delaney.
Maximilian Philipp, Mario Gotze and Andre Schurrle are among the more experienced players available.
Although Soldier Field is set to full to its 60,000 capacity, the sellout crowd will have to make do with a match lacking in the star quality you would expect from these two European giants.
While Dortmund are favourites due to be further ahead in their pre-season preparations, the narrow victory over Austria Wien does not suggest they are yet at their free-flowing best.
With both teams about to embark on three matches in the space of eight days, odds of 6/5 (2.20) seem generous on under 2.5 goals being scored in a slow-paced match disrupted by substitutions and lacking the usual star quality.