The Reds have been held in four of their last six league matches, a sequence of results that has seen Jurgen Klopp's side overtaken at the top of the Premier League table.
This fixture, however, gives the Reds a golden opportunity to return to winning ways. Remarkably, more than 44 years have passed since the Clarets last won at Anfield.
Despite their recent dip, Liverpool come into this one as strong favourites to pick up all three points. Klopp's men have won nine of their last 10 league matches on their own patch and are chalked up as a 2/13 (1.15) chance to come out on top.
Burnley have suffered back-to-back defeats at the hands of Newcastle United and Crystal Palace, respectively. The Clarets are just five points clear of the bottom three coming into this round of fixtures.
Dejan Lovren and Joe Gomez are again absent for the Reds. Alex Oxlade-Chamberlain is edging closer to a return, but is not yet fit enough to feature.
Steven Defour and Aaron Lennon miss the trip to Anfield for the Clarets.
Despite injuries to defensive personnel, the Reds have remained rock solid at the back in recent weeks. Indeed, Liverpool have chalked up no fewer than five consecutive clean sheets.
Should that form continue this weekend, Burnley may struggle to make much of an impact on Merseyside. William Hill go 4/6 (1.67) that the Reds keep a sixth successive clean sheet on Sunday and 3/4 (1.75) that Liverpool win without conceding.
Lack of spark
Liverpool have drawn a blank in three of their last four fixtures and much has been made of the Reds' perceived struggles in the final third. However, Klopp's side have scored at least three goals in six of their last seven league matches on their own patch.
The Reds, then, could run riot at Anfield once more on Sunday afternoon. William Hill's 11/10 (2.10) quote for Liverpool (-2) to beat the handicap mark could represent excellent value this weekend.