The Rome outfit ended last term in fifth place missing out on Champions League football by the narrowest of margins in what was an excellent campaign for Simone Inzaghi's side.
Lazio however suffered two of their heaviest defeats in the 2017/18 campaign to Napoli, losing 4-1 both home and away, and so it is no surprise the visitors are once more favourites on Saturday night.
Napoli have won five of their last six matches against Lazio and dabblebet offer them at 6/4 (2.50) to record another success.
Carlo Ancelotti has no major injury concerns ahead of his first game in charge of the Naples outfit, with the former Real Madrid boss likely to give a debut to new signing Fabian Ruiz in midfield.
Lazio's star midfielder Sergej Milinkovic-Savic is reportedly set for a loan move to Milan, which should be completed prior to this game.
No team scored more goals in Serie A last season than Lazio, although their defensive record was bettered by nine sides.
The trend of goals at both in Lazio matches should continue on Saturday night with the visit of one of the most exciting attacking sides in the Italian top flight.
Both teams to score is priced at 4/7 (1.57) and this selection has paid in four of the last seven meetings between the sides.
Tips and predictions
For higher odds however backing both teams to score and either to win at 13/10 (2.30) looks like an unmissable selection.
Both teams will feel they can win, and last season both demonstrated their ability to find the back of the net meaning this bet has a great chance of paying out this weekend.