Maurizio Sarri's side suffered a significant setback last weekend in their bid for a first Scudetto in 28 years as they crashed to a 4-2 defeat at the hands of Roma - only their second loss in the league this season.
Napoli, therefore, will be desperate to make an immediate return to winning ways and they can be backed at even money (2.0) with bet365 to take all three points in Milan.
Luciano Spalletti's side have lost just one of 15 home matches this season and they are an 11/4 (3.75) chance to inflict another blow on Napoli's title aspirations with a win. bet365 also go 12/5 (3.40) that the match ends all square.
Vlad Chiriches remains sidelined for the visitors with a bicep injury, whilst Faouzi Ghoulam remains out with a fractured kneecap.
Inter will be without the injured trio of Leandrinho, Tommaso Berni and Assane Gnoukouri for this clash.
Napoli have scored at least twice in six of their last eight matches and bet365 go even money (2.0) that Sarri's side score more than one goal at San Siro.
The same firm offer 19/20 (1.95) that there are at least three goals in the game - that selection would have landed in four of Napoli's last six fixtures.
Preview and predictions
Inter have won just two of their last 13 matches inside 90 minutes and so Napoli could be good value to get their title bid back on track in Milan.
Before being beaten by Roma, Sarri's side had chalked up 10 successive wins in Serie A and it is bet365's even money (2.0) quote for Napoli to get back to winning ways may offer a path to profit this weekend.
Odds correct at time of writing. Please gamble responsibly.