Icardi's 18 goals in 22 league matches has taken him one short of three figures in the Italian top flight, 89 of them coming for the Nerazzurri.
His form this season reignited speculation he could swap Milan for Real Madrid, but Inter held onto their prize asset during the January transfer window.
Luciano Spalletti has not been able to use Icardi since the deadline, though, as the striker missed last weekend's encounter with Crotone due to a muscle injury.
And he will be absent once more when Bologna visit Milan, with Italy international Eder expected to lead the line again.
"Unfortunately, Icardi cannot be a part of the match, he tried to stay with the group but in the movements with the ball he feels a bit of pain," Spalletti said.
"The tests done with the doctors led to the conclusion that it is better to wait."
Inter have dropped to fourth in the Italian top flight, having drawn six and lost two of their last eight league games.