The Terriers will have Mark Hudson in temporary charge following David Wagner's departure on Monday evening but the former defender could barely face a stiffer opening test.
Huddersfield were hammered 6-1 when they last faced City and furthermore, they have failed to win any of their last 10 matches in all competitions.
Given the apparent gulf in class between the teams, it is unsurprising that SportPesa make Manchester City their 4/27 (1.15) favourites.
City have no fresh concerns. Sergio Aguero, who hit a hat-trick against Huddersfield in August, could return to the starting line-up here. Gabriel Jesus, though, is surely pushing for a spot after scoring seven goals in his last three games.
Abdelhamid Sabiri, Tommy Smith and Aaron Mooy all miss out again for the Terriers.
Huddersfield have scored just 13 league goals so far this season - scoring just three times in their last eight games in all competitions.
City have scored 19 goals without reply in their last three games, including thumping 7-0 and 9-0 wins in cup competition, and no side has scored more frequently than the men from Manchester in the top tier this term.
Without a win in 10 matches, the Terriers look to be destined for the drop.
Manchester City have been ruthless in recent weeks and this could prove to be something of a one-sided contest, so it is SportPesa's 11/10 (2.10) quote for Manchester City (-2) to beat the handicap mark could represent real value ahead of Sunday's showdown.