The two African giants will clash in the 2019 Africa Cup of Nations (Afcon) qualifier at the FNB Stadium in Johannesburg.
“Obviously when you play the Nigerians or any West African teams you have to be ready mentally because they will bully you around,” Kekana told the media.
Kekana is expected to start in midfield in the absence of regulars Dean Furman and Kamohelo Mokotjo, who are both out injured.
The Mamelodi Sundowns captain is likely to face Nigeria's midfield duo of Oghenekaro Etebo and John Ogu in the middle of the park.
“It’s for us to really fight and try to protect our home game – we are going to try by all means to win the match," he continued.
South Africa head coach Stuart Baxter could partner Kekana with his Sundowns teammate Tiyani Mabunda in midfield.
Kekana is not concerned about who the coach decides to go with against the Super Eagles.
“The personnel really doesn’t matter that much. We’ve got the responsibility to represent our country. So, the goal is just to win the match," he added.
“Whoever plays must do their best for the country, the three points is all that matters," he concluded.
Bafana are unbeaten in the campaign and they're yet to concede a goal after four matches.
They find themselves in second position on the Group E log, a point behind the Super Eagles who are strong favourites to qualify for next year's Afcon finals in Cameroon.