The ex-West Ham man wears the armband for his side and will sit just behind sole striker Valere Germain in a 4-2-3-1 line-up.
He is joined by Lucas Ocampos and Florian Thauvin in Marseille's creative axis, while former Bayern man Luiz Gustavo starts at centre-back tasked with keeping Griezmann under wraps.
Griezmann, meanwhile, is joined by Diego Costa up front for the Colchoneros in a two-man attack.
There is also a place for Angel Correa, while Sime Vrsaljko starts on the right side of defence and Lucas Hernandez plays on the left.
Marseille: Mandanda; Sarr, Rami, Luiz Gustavo, Amavi; Sanson, Anguissa; Thauvin, Payet, Ocampos; Germain.
Subs: Sakai, Kamara, Rolando, Mitroglou, Njie, Pele, Lopez.
Atletico Madrid: Oblak; Vrsaljko, Godin, Gimenez, Lucas; Correa, Saul, Gabi, Koke; Costa, Griezmann.
Subs: Filipe Luis, Thomas, Torres, Savic, Juanfran, Gameiro, Werner.