With Real Madrid scoring in a record 33 consecutive home games in the Champions League and Napoli finding the back of the net in 10 of the 11 away matches they have played since the tournament's inception, goals seem to be on the cards at the Bernabeu.
The Neapolitans arrive in the Spanish capital as the top scoring side in Serie A, and 16 of their 57 goals in the Italian top flight have come from Dries Mertens. The Belgium international forward has also netted four of Napoli's 11 goals in this season's Champions League and is the shortest priced player for the visitors to find the back of the net, offered at 2/1 (3.00) to score anytime by Betfair.
Mertens leads the betting for Napoli along with Arkadiusz Milik, and the Polish striker, who is returning from a serious injury, is offered at the same price. Milik, of course, missed four months of the season and in his place Jose Callejon helped chip in with some important goals. The former Real Madrid wideman is Napoli's second top scorer domestically and is offered at 13/5 (3.60) to net on his return to the Bernabeu.
The hosts, meanwhile, boast the top scorer in the history of the competition, and Cristiano Ronaldo is offered at 8/15 (1.53) to continue his impressive run of scoring in the last 16 of the Champions League.
Ronaldo has netted in each of the last 10 matches he has played at this stage, scoring both home and away for Real Madrid in each of the last five years at this stage of the competition.
This season, though, it is Karim Benzema who is Real Madrid's top scorer in Europe, with the Frenchman having four goals to his name.
Benzema has been under a little pressure of late following just one goal Madrid's last nine La Liga matches, but the 28-year-old has an affinity with the Champions League and often saves his best performance for this competiton.