The bad news is that they need to score at least three goals in the second leg to keep alive their hopes of lifting the first piece of silverware of the season. The good news is that the Catalans have scored at least three times in three of their last four visits to the Bernabeu and recent Clasicos in the Spanish capital have been enthralling spectacles.
The most recent meeting came back in April when Lionel Messi scored an injury time winner in a 3-2 victory for the Blaugrana and the Argentine will once more be relied on for goals.
Messi is the top scorer in the history of this fixture and bet365 offer him at a the tempting price of evens (2.00) to add to his tally of goals against Barca's eternal rival. His strike partner Luis Suarez is offered at the same price, while Messi is available at 7/2 (4.50) to open the scoring and Suarez can be backed at 9/2 (5.50).
One of Barcelona's problems is that apart from their front two, their starting line-up seems devoid of other goal threats, with the departure of Neymar underlining the dependence on their two main forwards. Ivan Rakitic scored a beautiful strike in the Catalans' last visit to the capital and is offered at 5/2 (3.50) while Sergio Busquets missed a great chance in the first leg and is priced at 10/1 (11.00).
Cristiano Ronaldo will be missing following his first leg sending off of course, yet Los Blancos seem to have more players likely to score than their opponents. Already this season the likes of Isco, Marco Asensio and Casemiro have all found the back of the net, and having goal threats all over the pitch is one of the reasons why Zinedine Zidane's team have scored in 67 consecutive matches.
More tempting perhaps is the price of 7/4 (2.75) for Isco to score at anytime with the Spain international also available at 7/1 (8.00) to break the deadlock. Having scored in the UEFA Super Cup against Manchester United and put in a sensational performance at the Camp Nou, the 25 year old has begun the current campaign in the same impressive fashion with which he finished the previous season and looks a decent price to net once more.