The Black Stars have taken maximum points from their opening two matches, beating Uganda and Mali respectively, and Avram Grant's charges can make it a hat-trick of wins when they line up against Egypt on Wednesday.
The Pharaohs were held to a disappointing goalless draw against Mali in their opening group game, but Abdalla El Said's late strike saw Hector Cuper's men claim a vital 1-0 victory against Uganda last time out.
Consequently, a point from this match would be enough to see Egypt ease into the quarter-finals of the competition, while the Pharaohs will pip Ghana to top spot in Group D with a victory.
Grant's Ghanaians are chalked up as a 23/10 (3.30) with Betfair Sportsbook to seal their place in the last eight in style by winning this one, while Cuper's charges are available at 12/5 (3.40) with the same firm to take top spot by coming out on top; a draw would suit both sides and, as such, the 11/10 (2.10) quote offered up by Betfair Sportsbook for the match to end in stalemate may well prove popular with punters.
Neither of these two teams has conceded a goal since the tournament got underway and the odds compilers are anticipating another tight tussle here, with Betfair Sportsbook offering just 2/7 (1.29) that fewer than three goals are scored when these nations renew their rivalry.
Ghana are available at a 23/20 (2.15) to keep a clean sheet against the Pharaohs, while Grant's side are chalked up at a chunky 11/4 (3.75) to win without conceding - a selection that would have seen punters profit from four of Ghana's last five wins.
Given that there have been fewer than three goals scored in each of Ghana's last nine games - as well as in 12 of the Pharaohs' last 13 fixtures - the 2/7 (1.29) quote for the trend to continue in this tie is a solid selection.
There have been fewer than two goals scored, though, in each of the previous four fixtures in Group D and, with victory essential for neither team, another low-key clash looks likely here.
Punters, therefore, are advised to back fewer than two goals to be scored at 10/11 (1.91) with Betfair Sportsbook ahead of Ghana's Cup clash with Egypt on Wednesday night.