Having already fallen seven points behind rivals Barcelona, Zinedine Zidane's men simply cannot afford to slip-up when they visit Coliseum Alfonso Perez on Saturday.
And with Isco in a brilliant spell of form, dabblebet have enhanced the Spain midfielder to score first in a Real Madrid win from 13/2 (7.50) to 15/2 (8.50), with customers of the online sportsbook able to watch and bet on this fixture via desktop, mobile and tablet. Your account must be funded or active in order to see the action live.
Cristiano Ronaldo is in a rare dry spell in the league and both Gareth Bale and Karim Benzema are out injured, Isco has stepped up to become Real Madrid's top performer in attack this season.
The Spain star struck twice in a 2-0 win at home to Espanyol last time out before the international break and he took his form into the international break with a goal for his country in a win over Albania.
Real Madrid have won 14 of their last 15 games against Getafe and there are few signs of a shock result in Saturday's clash, so 15/2 (8.50) enhanced from 13/2 (7.50) on Zidane's men to win with Isco opening the scoring looks great value.
Although the champions have struggled in their home matches this season, they have a perfect five wins out of five when on the road this season, while their record against Getafe in recent years is brilliant.
Madrid have racked up 7-3, 4-1 and 5-1 wins against Getafe in the last three meetings between the clubs, so another big scoreline looks to be on the cards on Saturday when Madrid could cut the gap to Barcelona.