The Cottagers are back to the English top-flight for the first time since 2014 but things started on a bad note when they lost 2-0 at home to Crystal Palace on the opening weekend.
Now up against another fellow London club, the 2018 Championship Play-Off winners are the clear underdogs for this tie at odds of (10.00).
A stalemate looks unlikely but it’s (5.70) should it go that way at Wembley.
Harry Kane seems to have bad luck with the month of August, failing to score despite playing 14 league games, 988 minutes and attempting 46 shots.
Having drawn a blank for the entire 90 minutes last week, the Spurs Academy graduate will hope he can break the barren spell and BetKing has offered him at the price of (3.35) to opening proceedings in London and (1.48) to score anytime.
Punters who are convinced his bad luck will continue have odds of (2.35) to prevent him from hitting back of the net.