The side from the capital head to the north-east of the country following five successive defeats and that run does not look like improving this weekend.
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Barca have a midweek Champions League last 16 second leg tie with Lyon on Wednesday evening but Valverde is likely to field a full-strength side on Saturday with Thomas Vermaelen and Rafinha the only injured absentees, while Clement Lenglet is suspended.
Midfielder Gorka Elustondo is Rayo's only injury concern.
Rayo have, without doubt, deserved more from their run of five successive defeats, with Michel's men punished by some late goals.
They very nearly beat Barcelona in Vallecas earlier this season but conceded twice in the last three minutes to lose by a 3-2 scoreline.
The Madrid outfit have scored in each of their last four away matches while also finding the back of the net in each of their last four meetings with Barca.
Rayo are unlikely to cause the Blaugrana as many problems as they did back in November but they will certainly feel they can score at the Camp Nou.
Tips and predictions
Both teams to score is priced at 19/20 (1.95) and this looks like an attractive option, with this bet paying out the last four time these sides have met.
Odds correct at time of writing. Please gamble responsibly.