Even at their best, it would be expected that the Greek champions would struggle badly on a visit to Catalonia, yet Olympiakos have made an extremely poor start to their domestic campaign - picking up just 11 points from their opening seven matches and currently sit fourth in the Super League.
In Europe, the Pireaus outfit have lost both matches, going down 3-2 at home to Sporting and 2-0 away to Juventus, and they head to the Camp Nou badly out of form having won just two of their last eight in all competitions.
Barcelona, meanwhile, are unbeaten this season in all major competitions and at home in the Champions League they boast a formidable record; since losing to Bayern Munich back in May 2013, Barca have won 20 and drawn two of the ensuing European 22 games at the Camp Nou and their opponents on Wednesday are unlikely to taint that record.
Dabblebet offer the hosts 1/14 (1.07) while Olympiakos are priced at 28/1 (29.00), and despite being seasoned European campaigners, the Greeks have a poor away record and have lost seven of their last nine matches on the road in the competition.
A home win looks almost guaranteed and finding an angle to back Barca in such a one-sided market looks tough; over 3.5 goals in the game is offered at 6/10 (1.60), while Barca to win by three goals or more is priced at 4/7 (1.57).
Perhaps more appealing is investing in a game with 4-6 goals in it, which is offered at evens (2.00). This bet pays out with a home wins by 3-1, 3-2, 4-0, 4-1, 4-2, 5-0, 5-1 and 6-0 scorelines and realistically covers plenty of options if we are looking to back a comfortable victory for Ernesto Valverde's men.
Last season Barca beat both Manchester City and Borussia Monchengladbach 4-0 at home in the group stages and having despatched Juventus 3-0 in their opening home match this term, another high scoring Catalan home win looks likely.