Only Sergio Aguero and Mohamed Salah have scored more Premier League goals this season than Pierre-Emerick Aubameyang, who is William Hill's 7/2 (4.50) favourite to open the scoring at the Emirates Stadium.
The Gabon international missed a last-minute penalty in last weekend's North London derby draw with Tottenham, but can be backed at even odds (2.00) to redeem himself by firing past the Red Devils for the second time this campaign.
Meanwhile, Alexandre Lacazette is looking to become only the second Arsenal player after Thierry Henry to score in six consecutive home Premier League games, and is priced at 13/10 (2.30) to equal that record in high profile circumstances here.
On target three times in his last five league matches for Unai Emery's men, Henrikh Mkhitaryan is on offer at 9/5 (2.80) to come back to haunt his former club with a high profile goal.
However, the biggest threat is most likely to be found at the other end of the pitch, where Romelu Lukaku has struck six times in just his last three appearances.
Joining Lukaku on the scoresheet in Wednesday’s Champions League win over PSG to take his tally to seven goals in 14 starts since Ole Gunnar Solskjaer took over, Marcus Rashford is another tempting bet at 8/5 (2.60).
Returning to the line-up after missing the trip to Paris through suspension, Paul Pogba is a potential match-winner available at 19/10 (2.90) to take his tally for the season to 15 goals in all competitions.