Selected in a central position recently, Eden Hazard should return to a deeper role once the on-loan Juventus striker is integrated into the starting line-up.
Nevertheless, 10 goals in 18 league starts this season underline the Belgium star's threat from any position, and he is the Blues' 9/2 (5.50) favourite with William Hill to open the scoring at the Emirates Stadium, or 13/10 (2.30) to strike anytime.
Second behind Hazard in the scoring charts for Maurizio Sarri's team, Pedro is available at 29/20 (2.45) to add to his seven league goals for the campaign by scoring past the Gunners' defence for the second time this season.
Higuain's arrival will be particularly welcome given Olivier Giroud's poor output of four goals in 30 league games since joining the club last January, although he can be backed at 13/8 (2.63) to come back to haunt his former club with a rare goal on his old stomping ground.
However, it is Giroud's replacement at the Emirates Stadium who looks the most likely candidate to steal the headlines, with Pierre-Emerick Aubameyang having scored 15 goals in 18 Premier League home games since joining from Dortmund a year ago.
Aubameyang's goal tally in the league is currently twice that of strike partner Alexandre Lacazette, who is priced at only a slightly longer 8/5 (2.60) to get on the scoresheet for just the second time in nine league fixtures.
In contrast, Alex Iwobi is in relatively prolific form by his standards after scoring twice in six matches, and could offer tempting value at 9/2 (5.50) against a Chelsea defence he scored past at Stamford Bridge earlier in the reverse encounter.