The Swede striker and his Armenian team-mate were rested in Sunday's 2-0 victory over Premier League table-toppers Chelsea.
But both return to the line-up as Jose Mourinho reverts to a side showing a great similarity to the one which started last week's 1-1 draw with the Belgian side in Brussels.
Luke Shaw comes in for Matteo Darmian at left-back in the only change from the team which dominated the first leg, while there are five changes in total from the weekend with Ander Herrera and David de Gea the most high-profile absentees.
There is still no place in the starting XI for Anthony Martial, who has been asked by Mourinho to make a greater effort to deliver the things the manager has asked of him. The Frenchman instead has to settle for a place on the bench alongside Wayne Rooney, who returns after almost three weeks out with a double ankle injury.
Man Utd XI: Romero, Valencia, Bailly, Rojo, Shaw, Carrick, Pogba, Lingard, Mkhitaryan, Rashford, Ibrahimovic. Subs: De Gea, Fellaini, Blind, Rooney, Martial, Young, Herrera.
Anderlecht XI: Ruben, Appiah, Mbodjui, Spajic, Obradovic, Deondoncker, Tielemans, Hanni, Chipciu, Acheampong, Teodorczyk. Subs: Boeckx, Deschacht, Bruno, Nuytinck, Capel, Kiese Thelin, Stanciu