While the Porcupines will be hoping to keep their joint-lead in Zone A following the opening day win over Aduana Stars, the Phobians will be aiming to do same in Zone B.
In Tarkwa, CK Akonnor's outfit have it all to do against Medeama, who were not in action on matchday one. The Kumasi-based side will, however, will be without the injured duo of Wahab Adams and Dany Zabo Teguy.
Elsewhere in Zone A, Aduana, after the opening day setback, will look to bounce back with three points at home to Eleven Wonders, who succumbed to a 2-0 defeat to Ashanti Gold.
The Miners, meanwhile, face a tricky tie away at Bechem United. The Hunters are one of four sides who were not in action in week one.
The game between Stallions FC, formerly Wa All the, and Berekum Chelsea has been postponed. Both teams did not play on Sunday either.
In Zone B, Hearts' quest to make it six points in two games will be challenged when they play as guests to Elmina Sharks at the Nduom Sports Stadium. The latter held Inter Allies to a goalless draw away on Sunday.
After the home disappointment, the Eleven Is To One will be hoping to make amends in Sogakope where they face Wafa, who beat Liberty Professionals 3-1 on Sunday.
For the Scientific Soccer Lads, a home tie against Ebusua Dwarfs offers a prompt opportunity to appease their fans.
In the final match of the zone, Dreams FC and Karela United will lock horns in Dawu. While Still Believe lost 1-0 to Hearts on Sunday, Karela recorded a stunning 2-1 away triumph at Dwarfs.