Paulo Dybala's hat-trick gave Massimiliano Allegri's side the victory at MAPEI Stadium and maintained their 100 per cent start to their title defence.
Juve have also scored 13 times across the first four matchdays for the first time since the 1959-60 campaign.
Dybala, who took his tally to 52 Juve goals in all competitions in his 100th appearance, has scored in six consecutive Serie A games for the first time in his career.
13 - Juventus have scored 13 goals over the first 4 Serie A match-days for the first time since season 1959/60. Unstoppable. #SassuoloJuve— OptaPaolo (@OptaPaolo) September 17, 2017
He is also the first player to score in each of the opening four top-flight games since Luca Toni in 2005-06.
The Argentina star has eight league goals this season and 10 in total from just six appearances.