The Red Devils ended a four-game winless run when they defeated Everton 1-0 on New Year's Day and Jose Mourinho will be keen for his players to build on that as they come out the other side of a hectic festive schedule.
Derby, meanwhile, are enjoying a seven-game unbeaten streak in all competitions so they will fancy their chances of staging an upset against the Premier League giants.
|Game||Manchester United vs Derby County|
|Date||Friday, January 5|
|Time||20:00 GMT / 15:00 ET|
|Stream (US only)||fuboTV (7-day free trial)|
TV CHANNEL & LIVE STREAM
The game is not being shown live on television in the United Kingdom, but Goal will be providing updates here.
|US TV channel||Online stream|
In the United States (US), the FA Cup can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
SQUADS & TEAM NEWS
|Position||Man United players|
|Goalkeepers||De Gea, Romero, Pereira|
|Defenders||Lindelof, Jones, Rojo, Smalling, Blind, Shaw, Valencia, Darmian, Tuanzebe|
|Midfielders||Pogba, Mata, Lingard, Young, Herrera, Mkhitaryan, Matic, Mitchell, McTominay|
|Forwards||Lukaku, Martial, Rashford|
Manchester United are certain to be without a number of key first-team players with Eric Bailly, Michael Carrick and Zlatan Ibrahimovic all ruled out, but Marouane Fellaini could return.
Romelu Lukaku has been cleared to take part in the game following his head injury against Southampton, while Ashley Young is suspended.
Potential Man Utd starting XI: Romero; Darmian, Jones, Smalling, Shaw; Matic, Pogba, Lingard, Young; Martial, Rashford.
|Defenders||Forsyth, Shackell, Keogh, Baird, Wisdom, Pearce, Lowe, Hanson, Olsson, Davies|
|Midfielders||Anya, Lawrence, Johnson, Thorne, Ledley, Guy, Bird, Huddlestone|
|Forwards||Russell, Martin, Bent, Winnall, Weimann, Bennett, Vydra, Nugent, Thomas|
Derby have a number of injury concerns coming into the game, with Wales international duo Tom Lawrence and Joe Ledley both carrying knocks, while Bradley Johnson is also being monitored.
Rams boss Gary Rowett has indicated that he will make some "subtle changes" to his starting XI in order to cope with the busy schedule.
Potential Derby starting XI: Carson; Forsyth, Keogh, Davies, Baird; Huddlestone, Winnall, Vydra, Russell, Weimann; Nugent.
BETTING & MATCH ODDS
Manchester United are 1/4 favourites to win according to dabblebet, with Derby priced at 11/1 to beat the Red Devils. A draw is available at 9/2.
The festive period was undoubtedly a rocky patch for Man United and a series of disappointing results has seen them cede considerable ground to their rivals in the league as well as seeing them exit the Carabao Cup.
Mourinho's side suffered a humiliating last-minute elimination in the Carabao Cup quarter-final at the hands of another Championship side - Bristol City - and they will be desperate to avoid a repeat of that scenario when they take on Derby.
On paper, Rowett's Rams pose more of a threat to United than Bristol City did, boasting a plethora of experienced internationals in their squad, so it is certainly a game that the Red Devils cannot afford to take lightly by implementing mass changes.
That said, the busy schedule has taken its toll on the United squad, with injuries to Lukaku and Ibrahimovic handing Mourinho an unwelcome selection quandary, but the Portuguese will be buoyed by the performances of Jesse Lingard, who has shone in recent matches.