The 24-year-old linked up with City during the January transfer window earlier this year.
Laporte helped the Blues to wrap up a record-breaking title triumph in 2017-18 without suffering a reversal along the way.
He then contributed to City enjoying a 15-game unbeaten opening to the current campaign.
A rare setback was, however, to be suffered at Stamford Bridge , with Laporte seeing a 24-game sequence come to an end.
With the Blues having suffered a first loss of the season, they have been nudged down to second spot in the Premier League table.
Liverpool stretched their own unbeaten run on Saturday with a 4-0 demolition of Bournemouth.
Guardiola had been hoping to see his side follow that lead during a testing trip to west London.
Chelsea have been a thorn in his side before, though, and he was once again unable to mastermind their demise.
The most recent of those has Chelsea sat third in the standings - seven points back on City and eight adrift of the leaders.
They will be hoping to close those gaps over the coming weeks, while Laporte will be looking to open a fresh unbeaten run when the reigning champions play host to Everton next weekend.