Kane and Alli have been missing due to ankle and hamstring injuries respectively, with the England captain having initially expected to be unavailable until early March after he was hurt against Manchester United last month.
Wales left-back Ben Davies is also continuing to work his way back from a groin injury, but striker Vincent Janssen is unavailable for the visit of the Foxes due to a knee problem.
TEAM NEWS:— Tottenham Hotspur (@SpursOfficial) February 8, 2019
@dele_official (hamstring) and @HKane (ankle) have commenced on-field rehabilitation.
@Ben_Davies33 (groin) is continuing rehabilitation.
@vincentjanssen (knee) and @ericdier (virus) are unavailable this weekend. pic.twitter.com/AvjcpLPSZE
The first leg of the Dortmund tie is set to be played at Wembley on February 13, with the reverse match against the Bundesliga leaders scheduled for March 5.
The club has yet to confirm an official opening date, and that derby fixture will now take place at Wembley, where the club has played for nearly two full seasons as the stadium project has been hit by delays.