Antonio Conte's side are currently fifth in the division, five points adrift of fourth-place Tottenham with three games and nine points left to play for.
Clinching fourth - and thus Champions League football - relies heavily on Spurs slipping up, but the Blues must also collect maximum points in their remaining games.
The Reds, meanwhile, can move closer to securing a third-place finish, and they come into the game on a high after booking their place in this year's Champions League final.
|Game||Chelsea vs Liverpool|
|Date||Sunday, May 6|
|Time||16:30 BST / 11:30 ET|
|Stream (US only)||fuboTV (7-day free trial)|
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|NBCSN / Telemundo||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on Sky Sports Premier League and it can be streamed live online using Sky Go.
|UK TV channel||Online stream|
|Sky Sports Premier League||Sky Go|
Squads & Team News
|Goalkeepers||Caballero, Courtois, Eduardo|
|Defenders||Rudiger, Alonso, Zappacosta, Cahill, Christensen, Azpilicueta, Luiz, Emerson, Ampadu, Sterling, Chalobah|
|Midfielders||Fabregas, Drinkwater, Kante, Barkley, Hazard, Pedro, Moses, Willian, Bakayoko, Scott, Hudson-Odoi|
Chelsea welcome Marcos Alonso back into the fold after the Spaniard served a three-match suspension. However, David Luiz, Danny Drinkwater and Ethan Ampadu remain sidelined.
Potential Chelsea starting XI: Courtois; Christensen, Azpilicueta, Cahill; Alonso, Moses, Fabregas, Kante, Hazard, Willian; Giroud.
|Goalkeepers||Karius, Mignolet, Ward|
|Defenders||Clyne, Van Dijk, Lovren, Gomez, Moreno, Robertson, Klavan, Matip, Masterson, Alexander-Arnold, Williams|
|Midfielders||Wijnaldum, Milner, Henderson, Lallana, Oxlade-Chamberlain, Can, Jones, Woodburn, Camacho|
|Forwards||Salah, Mane, Firmino, Solanke, Ings, Brewster|
Jurgen Klopp gave a positive update on Adam Lallana, who has been training and may come into the squad, but Joe Gomez remains out of action. Emre Can, meanwhile, is also out of action as he struggles to recover from a back injury.
Alex Oxlade-Chamberlain and Joel Matip are both definitely out.
Potential Liverpool starting XI: Karius; Clyne, Van Dijk, Lovren, Moreno; Milner, Henderson, Wijnaldum; Salah, Firmino, Mane.
Betting & Match Odds
Home side Chelsea are favourites to win according to dabblebet, who offer odds of 5/4 on the Blues. Liverpool are available at 11/5 and a draw is a 12/5 bet.
Both sides have finals to look forward to later this month and the feeling is that those games will heavily inform the kinds of teams that are sent out in the upcoming fixtures.
Chelsea, who are desperately hoping to steal a fourth-place finish, have three crucial league games to play before facing Manchester United in the FA Cup final on May 19, while Liverpool have just two and a lengthy break before they take on Real Madrid in the Champions League final on May 26.
However, Conte believes that his opposite number Klopp will be instructing his players not to take their foot off the pedal in the remaining league games. "For sure Liverpool will want to finish this season in the best possible way. I don’t think the game in the Champions League will influence them," the Blues boss told reporters.
Conte added: "Our focus is to finish in the best possible way and fight for a Champions League place. The situation is not in our hands but we have to try and the way to start is three points against Liverpool. We have another final in the FA Cup and for sure we have to give satisfaction to all our fans. We want to try to do our best to the end."
Games against Huddersfield Town and Newcastle United follow the clash against Liverpool and a victory over the Merseysiders would serve as a timely boost for the London outfit as they attempt to pull off the seemingly impossible.