The Super Falcons attacker was introduced as an 87th-minute substitute in Saturday's final which made it her third appearance in the competition.
With Lluis Cortes' side trailing 4-0, the Dalian Quanjian loanee found the back of the net in the 89th minute but it was not enough to inspire her team's fight back.
The effort was Oshoala's maiden goal in the Women's Champions League this season and her eighth goal after 11 matches for Barca.
I would like to appreciate this moment , FIRST EVER NIGERIAN /AFRICAN TO PLAY IN A uefa champions league final GAME , FIRST EVER NIGERIAN /AFRICAN PLAYER TO SCORE IN A uefa CHAMPIONS LEAGUE FINAL GAME, FIRST PLAYER TO score fc Barcelona FIRST uefa champions league final GOAL.🇳🇬🇳🇬 pic.twitter.com/RQknnYNHiM— ASISAT M.O.N (@AsisatOshoala) May 19, 2019
After her impressive performances with the Spanish giants this term, she will hope to replicate her form for Nigeria at the Women's World Cup scheduled to begin next month in France.