The Western Sydney Wanderers will be without star players Alexander Baumjohann and Oriol Riera for three weeks after both sustained injuries on Tuesday.
Suspensions also loom large this weekend with a number of players stuck on the sidelines due to bans.
In some good news, Adelaide United's German midfielder Mirko Boland is fit again after a few weeks out.
Here's every club's unavailable players for Round 13 and beyond...
Adelaide United absentees: 9.Baba DIAWARA (knee), 18.Lachlan BROOK (knee), 33.Apostolos STAMATELOPOULOS (quad)
Brisbane Roar absentees: 4.Daniel Bowles (suspended – 1 match), 6.Avram PAPADOPOULOS (glute),10.Brett HOLMAN (knee), 13.Stefan MAUK (groin)
Central Coast Mariners absentees: 20.Kalifa CISSE (suspended – 1 week), 13.Aiden O’NEILL (suspended – 1 week), 21.Corey GAMEIRO (calf)
Melbourne City absentees: 27.Florin BERENGUER-BOHRER (calf)
Melbourne Victory absentees: Jai INGHAM (quad – TBC), Keisuke HONDA (Hamstring – 4 weeks), Nick ANSELL (Hamstring – TBC), Georg NIEDERMEIER (Calf – TBC)
Newcastle Jets absentees: 10.Ronald VARGAS (suspension – 1 week), 40.Noah JAMES (gk) (not selected), 5.Ben KANTAROVSKI (groin – 4 weeks), 24.Joe CHAMPNESS (foot – TBC)
Perth Glory absentees: Chris IKONOMIDIS (International Duty)
Sydney FC absentees: 3.Ben WARLAND (foot – 1 weeks), 5.Jop van der LINDEN (hamstring – 2 weeks), 12.Trent BUHAGIAR (ACL – indefinite), 19.Chris ZUVELA (knee – indefinite), 23. Rhyan GRANT (International Duty)
Wellington Phoenix absentees: 14.Alex RUFER (suspended - 1 week), 4.Mandi Sosa (Suspension - 1 week)
Western Sydney Wanderers absentees: 9.Oriol RIERA (injury - 3 weeks), 10.Alexander BAUMJOHANN (injury – 3 weeks), 16.Josh RISDON (international duty), 19.Mark BRIDGE (injury – 2 weeks)