These two teams experienced contrasting fortunes in the FA Cup third round last week as Mauricio Pochettino's team were comfortable 3-0 winners against AFC Wimbledon, while Sam Allardyce's side suffered a heartbreaking 2-1 defeat against Merseyside rivals, Liverpool, at Anfield.
Spurs were held to a 1-1 draw against West Ham United in their opening home league fixture of 2018, so Pochettino's team will be keen to get back to winning ways in the top tier when they take on the Toffees.
The Londoners have won 10 of their last 13 matches at Wembley in all competitions and they are chalked up as dabblebet's 1/4 (1.25) favourites to take all three points from Saturday's showdown, while the same firm offer 5/1 (6.0) that this match remains deadlocked at the end of 90 minutes.
Everton's cup defeat last weekend means that they have now failed to win any of their last five matches so will be keen to get back on track here, and dabblebet offer a chunky 12/1 (13.0) the men from Merseyside claim a vital victory - and improve their dismal record of having won just one of their last 19 Premier League fixtures away from Goodison Park.
Christian Eriksen, Dele Alli and Heung-Min Son were all named as substitutes for last weekend's FA Cup tie against AFC Wimbledon - with the latter two coming off the bench - but the key trio should return to the starting line-up against the Toffees.
Allardyce is expected to hand new singing, Cenk Tosun, his Everton debut after the Turkey international completed a big-money move from Besiktas last week.
Spurs to claim a comfortable win?
There has been, at least, a two goal margin of victory in each of the last seven matches that Spurs have won; dabblebet offer 4/6 (1.67) that Pochettino's men win by more than a single goal on Saturday evening.
Everton will hope that the addition of Tosun to their ranks makes a significant difference, for the Toffees have failed to find the net in three of their last four Premier League matches; dabblebet offer 8/13 (1.62) that the Toffees draw a blank at Wembley.
Tips and predictions
Spurs, however, have managed just one clean sheet in their last five Premier League matches at Wembley and the visitors will feel that they are more than capable of making their mark in this match.
Pochettino's side edged a five goal thriller when these teams met at White Hart Lane last season and dabblebet's 13/10 (2.30) quote for both teams to score could offer good value for punters ahead of Saturday's match at Wembley.