Cristiano Ronaldo will come up against some familiar faces when he leads his country in their first group game at the World Cup.
A strike here would see him become just the fourth man to score at a fourth different World Cup, joining Pele, Uwe Seeler and Miroslav Klose in the record books.
Ronaldo is the shortest priced Portuguese player to find the back of the net with dabblebet offering him at 7/5 (2.40).
Any time the 33-year-old is priced at odds-against to score it is worth considering, while he can be backed at 4/1 (5.00) to open the scoring.
Who will start for Spain?
Julen Lopetegui had previously admitted he did not know who would start the Portugal game at striker for Spain, but it will now be down to new coach Fernando Hierro to make the decision.
Of the three, Aspas seems to be in the best form and fits the Spain system well, although it is tough to know whether he will feature especially given all the upheaval surrounding the team.
Tips and predictions
With plenty of question marks around who will play up front for La Roja there is perhaps more value in backing one of their hugely talented midfielders to score.
Isco is priced at 11/5 (3.20) to score at anytime and the Real Madrid player has been in excellent scoring form for his country, netting seven times in his last seven international games.