Last week's 3-0 win at the Estadio Wanda Metropolitano in the Europa League has allowed Atletico Madrid to travel to Lokomotiv Moscow without too much pressure.
Barring a monumental upset, Diego Simeone's men will surely book their place in the quarter finals and maintain their status as tournament favourites.
Latest odds
The La Liga side were comfortably superior in the first leg last Thursday, and SportPesa offer them at a healthy evens (2.00) to win in the Russian capital.
Lokomotiv, whose domestic season has just recently restarted after the winter break, can be backed at 61/20 (4.05) and the draw is available at 47/20 (3.35).
Team news
Strikers Diego Costa and Kevin Gameiro have not travelled to Russia, while goalkeeper Jan Oblak may be rested.
Next Match
Lokomotiv's top scorer Jefferson Farfan picked up a muscle injury in the previous round against Nice, but could be in contention for a return.
Atletico to grind out a result in Moscow
There are few teams in Europe better at defending a lead than Diego Simeone's side and with a 3-0 first leg advantage, expect Los Rojiblancos to see out a positive result in Russia.
The visitors will not necessarily be going for goals, but they are more than capable of keep another clean sheet in what should be a low-scoring game.
Tips and predictions
Atletico are priced at 13/10 (2.30) to keep a clean sheet and that looks like an extremely tempting option.
Madrid have kept clean sheets in their away trips to Qarabag and Roma in the Champions League earlier this season, while domestically they have kept clean sheets in eight of their last 11 La Liga matches.
Also worthy of consideration is backing under 1.5 goals in the game at 7/4 (2.75), which should have a good chance of paying out.
Atletico Madrid clean sheet at 13/10 (2.30) for a 2pt stake with SportPesa 
