The Benfica great lifted the European Cup with the Aguias in 1962, was named European Footballer of the Year in 1965 and scored nine goals at the 1966 World Cup.
He is rightly regarded as one of the greatest players to ever play the game, with tributes flooding in from some of football's finest via Twitter, as reaction to his death gathers pace.
Goal rounds up the latest tweets from across the globe, with two more of Portugal's finest footballers paying their respects along with a host of respected figures and institutions.
TRIBUTES IN TWEETS
Always eternal #Eusebio, rest in peace
RIP Eusebio (1942-2014). One of the greats
The king!! Grande perda para todos nos! O mais grande!!
Sad to hear that Eusébio has passed away. 733 goals in 745 appearances will always mark him down as a true legend of the game. R.I.P.
Respect to a man who meant so much to the game I cherish. Eusebio, one of the all time greatest, may he Rest In Peace.
We're saddened to hear Benfica legend Eusebio has passed away. He was a fantastic player and a friend of the club.
Old friends | Eusebio and Bobby Charlton did battle at the 1966 World Cup
Football has lost a legend. But Eusebio’s place among the greats will never be taken away (1/2)
Eusebio was a football & FIFA ambassador. He’ll be sorely missed. Rest in peace Black Panther (2/2)
One of the greatest football players ever has passed away. My friend Eusebio died last night. My thoughts are with his family.
A great footballer left us and I want to say thanks to Eusébio for all his greatness and beautiful football moments that he gave us
Sad news that Eusebio has passed away, he was a true legend, a fantastic ambassador to football, a gentleman to the core. R.I.P. SirArsenal
Rest in peace, Eusebio - Portuguese football legend.
Gordon Banks told The Sentinel:
“He was one of those players who could do things with that heavy ball that very few in this country could do.
"He could hit it with the inside of his foot, the outside. It made me quite pessimistic when he was taking free-kicks."