Nasri has not been featured for les Bleus since Euro 2012, having been hit with a three-game ban by the French Football Federation (FFF) in relation to his conduct during the tournament.
While Nasri is included, Franck Ribery has been omitted due to the winger's upcoming club committments with Bayern Munich.
"He has to play two finals," former Juventus midfielder Deschamps pointed out, referring to die Roten's Champions League and DFB-Pokal clashes with Borussia Dortmund and Stuttgart, respectively.
"It is wiser after a busy season in which he has had a few knocks to leave him out."
Elsewhere, Porto defender Eliaquim Mangala and Saint-Etienne midfielder Joshua Guilavogui have both been called upon by their country for the first time, whilst Manchester United defender Patrice Evra has been left out.
"They are young players with good potential for the highest level," Deschamps said of the uncapped 22-year-old duo.
France are scheduled to face Uruguay in Montevido on June 5 and Brazil in Porto Alegre four days later.
France squad for friendlies versus Uruguay and Brazil
|Hugo Lloris||Tottenham Hotspur|
|Gael Clichy||Manchester City|
|Mathieu Debuchy||Newcastle United|
|Mamadou Sakho||Paris Saint-Germain|
|Yohan Cabaye||Newcastle United|
|Yoann Gourcuff||Olympique Lyonnais|
|Blaise Matuidi||Paris Saint-Germain|
|Samir Nasri||Manchester City|
|Bafetimbi Gomis||Olympique Lyonnais|
|Jeremy Menez||Paris Saint-Germain|