The summer arrival was forced off during the first half of Saturday's 1-0 loss to Stoke City with a suspected groin injury and will undergo scans on Sunday
The midfielder was forced off in the first half at the Etihad Stadium and replaced by fellow Brazilian Fernandinho and City boss Manuel Pellegrini revealed after the game that Fernando was set for further assessment.
"Fernando has a muscle problem in his groin," Pellegrini told reporters. "We will see tomorrow [Sunday] with the doctor how strong it is."
A break for international fixtures means City are not in action again until September 13, when they visit Arsenal.
The champions suffered their first defeat of the season against Stoke, with a fine solo goal from Mame Biram Diouf earning a shock victory for Mark Hughes' men.