Valladolid really went for Barca at the weekend, and City will have to show a similar intensity right from the start; if they do, it could be an uncomfortable evening for the hosts.
Yet the Blaugrana almost always score at home (having netted in each of their last 19 games at Camp Nou) and a repeat tonight would leave City needing to score three times to progress.
That is not an impossible task - last season, both Real Madrid and Bayern Munich scored three goals at Camp Nou while Valencia managed it in a Liga victory last month.
Both teams to score is offered at 4/7 (1.57) and if City are likely to net then Sergio Aguero looks must be considered as a goalscorer bet.
Aguero is offered at 15/8 (2.88) to net at anytime - something he has managed four times so far in his career against Barca and his strength and movement can cause problems to a defence which has shown itself to be uncomfortble when put under real pressure.
A bright start and a quick tempo are needed from City if they are record a famous comeback and the price of 5/4 (2.20) for City's first goal to come in the first half looks like a fantastic bet.
Barca have conceded in each of their last three matches and in each of those games, the Liga champions have let in goals within the opening 45 minutes.
|Manchester City first goal in first half at 5/4 (2.25) 2.0pt stake with Paddy Power|
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Phil Kitromilides is a sports journalist and TV presenter in Madrid