The Dutch frontman complained after Tuesday's 2-0 defeat to Olympiakos that his United colleagues were causing him difficulties and forcing him to adapt his game, and followed up that complaint by labelling United "lousy".
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But Chicharito holds a contrasting view to the former Arsenal forward, instead saying that he owes everything to the players around him.
The Mexican wrote on Instagram: “Without your team-mates you can't be somebody in football, always be thankful...”
If not a riposte to Van Persie's barbed comments, then Chicharito's post, which was accompanied by a photo of himself with left-back Patrice Evra, could allude to the French defender's possible departure.
As reported by Goal on Thursday, Evra, who is out of contract in the summer, is being lined up by Inter as they bid to strengthen their back-line – and the San Siro side are already closing in on fellow United defender Nemanja Vidic.