|25/1||Spurs are 25/1 with Bet365 to beat West Ham 3-2
The Hammers have conceded just five goals, however - only four sides have shipped less - and Holtby is aware that Spurs will have to be at their best to breach the away side's defence.
"West Ham aren't conceding many goals, they look strong and dangerous on the counterattack," the midfielder told Tottenham's official website.
"We have to be ready for it, another derby, the atmosphere will be fantastic and I hope for the fans we can get three points again."
The Germany international has been in impressive form for Tottenham this season and laid on an assist in the club's 2-0 Europa League win over Anzhi Makhachkala on Thursday.