The duo, who were doubts before the match, have recovered in time to feature for the Gunners while former Liverpool pair Raul Meireles and Dirk Kuyt start for the hosts
Elsewhere in the Gunners' line-up, Wojciech Szczesny takes his place in goal whilst Per Mertesacker, Laurent Koscielny, and Kieran Gibbs complete the back line.
Aaron Ramsey takes his place alongside Wilshere in front of the defence while Tomas Rosicky, Santi Cazorla and Theo Walcott form the attacking midfield trident behind sole striker Olivier Giroud.
Former Liverpool and Chelsea man Raul Meireles figures into the Turkish giants' midfield on the other side, with fellow ex-Liverpool winger Dirk Kuyt also starting for the Istanbul outfit.
Fenerbahce starting XI: Volkan; Bruno Alves, Yobo, Bekir, Kadlec; Mehmet Topal, Emre, Meireles, Kuyt, Sow, Webo.
Arsenal starting XI: Szczesny; Sagna, Mertesacker(c), Koscielny, Gibbs; Wilshere, Ramsey; Rosicky, Cazorla, Walcott; Giroud.