Paul Scholes, Patrice Evra, Nemanja Vidic, Rio Ferdinand, Ryan Giggs and David de Gea are all restricted to places on the bench for the match against West Brom at the Hawthorns
Michael Carrick will captain the Red Devils against West Brom as Nemanja Vidic, Patrice Evra, Paul Scholes, Rio Ferdinand and Ryan Giggs are restricted to places on the bench.
Anders Lindegaard starts in goal and Antonio Valencia is likely to fill in at right-back, with Robin van Persie, Chicharito and Shinji Kagawa leading the line.
Baggies boss Steve Clarke, meanwhile, leaves Romelu Lukaku on the bench as his team seeks to keep their grip on eighth place in the Premier League.
Swansea, who host Fulham at the Liberty Stadium, are two points behind West Brom and are the only team that can catch the Midlands club.
West Brom: Foster; Jones, McAuley, Olsson, Ridgewell; Yacob, Mulumbu; Dorrans, Morrison, Brunt; Long.
Subs: Myhill, Dawson, Tamas, Lukaku, Rosenberg, Popov, Fortune.
Manchester United: Lindegaard; Valencia, Jones, Evans, Buttner; Carrick, Cleverley, Anderson; Chicharito, Van Persie, Kagawa.
Subs: De Gea, Evra, Ferdinand, Giggs, Vidic, Scholes, Januzaj.