The Dutchman says it has been an honour to work with the 71-year-old, who will retire after 26 years and an incredible 38 trophies at Old Trafford at the end of the season
Following his £24 million move from Arsenal last summer, the 29-year-old's 25 goals this season have helped fire United to their 20th league crown.
Van Persie says it has been an honour to have worked under the 71-year-old, who will retire at the end of the season after 26 years at Old Trafford.
"I am really sad to hear that the manager Sir Alex is retiring, but I'm really happy I have had the opportunity and the honour to work with him," Van Persie posted on his official Facebook page.
"He is a great manager and above all even a greater person. I have to thank him for an amazing year and for making my dream come true by winning the league.
"I wish him and his family the very best."
Current Everton boss David Moyes will take over from Ferguson at the end of the season at the Old Trafford helm.