The Blues take on former manager Andre Villas-Boas’ side at Stamford Bridge with both clubs firmly in the hunt for a Champions League spot.
Hazard missed Chelsea’s 1-0 win at Manchester United on Sunday but is set for a return to the squad, while Benitez confirmed that John Obi Mikel and Ryan Bertrand will not feature.
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"Mikel is not available; he is still in some pain. Bertrand is not available with a problem with his knee, nothing serious.”
Benitez has made full use of the Chelsea squad, constantly rotating his side as the Blues have been forced to contend with a huge amount of fixtures in a short space of time.
"I think it's important to manage the squad and important for them,” he added.
“It doesn't matter if you pick one or the other, they all want to win and be a part of the important games."
The Chelsea boss acknowledged that the biggest threat to his side will be PFA player of the year Gareth Bale, while he was also full of praise for ex-Blues manager Villas-Boas.
"I think he is a good manager, he is working hard for his new team," Benitez added. "They're in a good position and doing well.
"Bale is very good, having a great season and scoring a lot of crucial goals for them. He is playing in different positions and doing well in all of them.
"The way we play, we have a good team with good players. We have to keep an eye on him but they have to keep an eye on ours."