The Dutchman will receive a guard of honour from his former team-mates on his first return to his old club as Sir Alex Ferguson's champions take on the Gunners
The Dutchman is named as part of a strong side, playing just ahead of Wayne Rooney, who will receive a guard of honour from the Gunners after confirming their 20th English title on Monday.
Arsenal manager Arsene Wenger has elected not to start Jack Wilshere, who continues to be eased back into action following injury, with Tomas Rosicky in his place behind the striker.
Lukas Podolski is the forward for the Gunners, with Olivier Giroud beginning his three-game suspension as Wenger makes just two changes from the side that beat Fulham, with Kieran Gibbs replacing Nacho Monreal, the only other change.
Arsenal starting XI: Szczesny; Sagna, Mertesacker, Koscielny, Gibbs; Arteta, Ramsey; Walcott, Rosicky, Cazorla; Podolski
Subs: Mannone, Vermaelen, Jenkinson, Monreal, Wilshere, Oxlade-Chamberlain, Gervinho
Manchester United starting XI: De Gea; Rafael, Evans, Ferdinand, Evra; Valencia, Carrick, Jones, Nani; Rooney, Van Persie
Subs: Lindegaard, Anderson, Giggs, Hernandez, Cleverley, Kagawa, Buttner