Manchester United can win the Premier League title with victory against Aston Villa on Monday, after rivals City slumped to a 3-1 defeat at Tottenham.
The Red Devils are 13 points clear of Roberto Mancini's men, and can extend that lead to an unassailable 16 with victory at Old Trafford.
United lost out on their 20th league crown in dramatic circumstances last season, but can make amends against Paul Lambert's strugglers.
It looked as though Sir Alex Ferguson's men would have to wait at least another week when City took an early lead against Spurs at White Hart Lane, but a seven-minute blitz saw Clint Dempsey, Jermain Defoe and Gareth Bale turn the match on its head.
League success would be Sir Alex's 13th with United during his 27 years in charge, while the Old Trafford club would move two clear of Liverpool, who have 18 titles to their name.