Chicharito has been dropped to the Manchester United bench with Wayne Rooney moving forward again as they face West Ham United.
The Mexican had looked set to be starting up front with Robin van Persie but Phil Jones's inclusion means that the English forward is free to return to his more natural position.
Elsewhere in the United side, Rafael is recalled at right-back while Ashley Young and Paul Scholes remain sidelined with ankle and knee injuries, respectively.
James Tomkins is left out of the West Ham side with a calf injury but Winston Reid begins the game after passing a late fitness test.
West Ham starting XI: Jaaskelainen, Reid, Nolan, Jarvis, Carroll, Vaz Te, O'Brien, Collins, Demel, Diame, O'Neil
Subs: C Cole, Collison, Maiga, Henderson, Taylor, Noble, Pogatetz
Manchester United starting XI: De Gea, Rafael, Evra, Jones, Ferdinand, Valencia, Rooney, Vidic, Carrick, Van Persie, Kagawa
Subs: Evans, Giggs, Chicharito, Nani, Welbeck, Cleverley, Amos